Searching for new thermally emitting isolated neutron stars in the 2XMMp catalogue - Discovery of a promising candidate

The group of 7 thermally emitting and radio-quiet isolated neutron stars (INSs) discovered by ROSAT constitutes a nearby population which locally appears to be as numerous as that of the classical radio pulsars. So far, attempts to enlarge this particular group of INSs finding more remote objects failed to confirm any candidate. We found in the 2XMMp catalogue a handful of sources with no catalogued counterparts and with X-ray spectra similar to those of the ROSAT discovered INSs, but seen at larger distances and thus undergoing higher interstellar absorptions. In order to rule out alternative identifications such as an AGN or a CV, we obtained deep ESO-VLT and SOAR optical imaging for the X-ray brightest candidates. We report here on the current status of our search and discuss the possible nature of our candidates. We focus particularly on the X-ray brightest source of our sample, 2XMM J104608.7-594306, observed serendipitously over more than four years by the XMM-Newton Observatory. A lower limit on the X-ray to optical flux ratio of ~ 300 together with a stable flux and soft X-ray spectrum make it the most promising thermally emitting INS candidate. Beyond the finding of new members, our study aims at constraining the space density of this population at large distances and at determining whether their apparently high local density is an anomaly or not.Comment: 3 pages, 2 figures, proceedings of the conference "40 Years of Pulsars", 12-17 August 2007, Montreal, Canad

The neurobiological basis of cognitive side effects of electroconvulsive therapy : a systematic review

Altres ajuts: M.C. is founded by the Sara Borrell postdoctoral contract [CD20/00189].Decades of research have consistently demonstrated the efficacy of electroconvulsive therapy (ECT) for the treatment of major depressive disorder (MDD), but its clinical use remains somewhat restricted because of its cognitive side effects. The aim of this systematic review is to comprehensively summarize current evidence assessing potential biomarkers of ECT-related cognitive side effects. Based on our systematic search of human studies indexed in PubMed, Scopus, and Web of Knowledge, a total of 29 studies evaluating patients with MDD undergoing ECT were reviewed. Molecular biomarkers studies did not consistently identify concentration changes in plasma S-100 protein, neuron-specific enolase (NSE), or Aβ peptides significantly associated with cognitive performance after ECT. Importantly, these findings suggest that ECT-related cognitive side effects cannot be explained by mechanisms of neural cell damage. Notwithstanding, S-100b protein and Aβ40 peptide concentrations, as well as brain-derived neurotrophic factor (BDNF) polymorphisms, have been suggested as potential predictive biomarkers of cognitive dysfunction after ECT. In addition, recent advances in brain imaging have allowed us to identify ECT-induced volumetric and functional changes in several brain structures closely related to memory performance such as the hippocampus. We provide a preliminary framework to further evaluate neurobiological cognitive vulnerability profiles of patients with MDD treated with ECT

Seminari de Metodologia en Toponímia i Normalització Lingüística (1er : 2005 : Palma)

Abstract not availabl